61: Calcium Channel Blockers
نویسندگان
چکیده
In 1964, Albretch Fleckenstein described an inhibitory action ofverapamil and prenylamine on excitation-contraction coupling that was similar to calcium depletion. By the late 1970s, the clinical use of calcium channel blockers (CCBs) was widely accepted for variety of cardiovascular indications, including hypertension, dysrhythmias, and angina. Later indications, including Raynaud phenomenon, migraine headaches, and subarachnoid hemorrhage, have been adopted. There are currently 10 individual CCBs marketed in the United States that are available as immediate or sustained-release formulations and as combination products with other antihypertensives.
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